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some reports say that 95 percent of rheumatoid arthritis patients take methotrexate to treat ra at some point.

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27 likewise, retinoids and trimethoprim have been known to interact with methotrexate to produce additive hepatotoxicity and haematotoxicity, respectively.

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an overdose of methotrexate or deficiency of the vitamin folic acid may result in anaemia decreased haemoglobin , leucopaenia reduced white cell count, risking serious infections , and thrombocytopenia low platelet count, resulting in bruising and bleeding .

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it may be used alone as an abortifacient or in combination with ru486, tamoxifen or methotrexate for terminating pregnancy.

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